Technology Frames: The Art of Perspective and Interpretation in Strategy

In this paper, I bring together the literatures of the economics of innovation, corporate strategy and managerial and organizational cognition to explore how and why companies come to different conclusions and strategies for technology when presented with essentially very similar situations and information. Building on the work of Orlikowski and Gash (1994) on technological frames, I seek to explore the role of the technology frame of key senior managers in defining corporate strategy with respect to technology. To provide an empirical basis for the study, I take the case of the 6 leading US vertically integrated oil companies involved in the exploration and production of petroleum during the period 1984 to 1997. The analysis considers two key salients for the technology frame which are operationalised for the six companies based on their R&D expenditures, patents, publications and contrasted with their operational performance measures. These salients reflect respectively adaptational mapping (whereby signals in the environment prompt adaptation) and formational mapping (whereby experience and path-dependency influence interpretation) within the technology frame. The findings indicate support for the proposed approach to proxying technology frames on the two key points of salience for the upstream petroleum industry, and the paper concludes with a short discussion of future lines of research.technology frames, upstream petroleum, technology strategy, adaptational mapping, formational mapping

Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility

Background: Germline genetic variation is associated with the differential expression of many human genes. The phenotypic effects of this type of variation may be important when considering susceptibility to common genetic diseases. Three regions at 8q24 have recently been identified to independently confer risk of prostate cancer. Variation at 8q24 has also recently been associated with risk of breast and colorectal cancer. However, none of the risk variants map at or relatively close to known genes, with c-MYC mapping a few hundred kilobases distally. Results: This study identifies cis-regulators of germline c-MYC expression in immortalized lymphocytes of HapMap individuals. Quantitative analysis of c-MYC expression in normal prostate tissues suggests an association between overexpression and variants in Region 1 of prostate cancer risk. Somatic c-MYC overexpression correlates with prostate cancer progression and more aggressive tumor forms, which was also a pathological variable associated with Region 1. Expression profiling analysis and modeling of transcriptional regulatory networks predicts a functional association between MYC and the prostate tumor suppressor KLF6. Analysis of MYC/Myc-driven cell transformation and tumorigenesis substantiates a model in which MYC overexpression promotes transformation by down-regulating KLF6. In this model, a feedback loop through E-cadherin down-regulation causes further transactivation of c-MYC. Conclusion: This study proposes that variation at putative 8q24 cis-regulator(s) of transcription can significantly alter germline c-MYC expression levels and, thus, contribute to prostate cancer susceptibility by down-regulating the prostate tumor suppressor KLF6 gene

Cheilostome bryozoan diversity from the southwest Atlantic region: Is Antarctica really isolated?

During the Cenozoic, the break-up of Gondwana was accompanied by a gradual separation of its components and the subsequent establishment of the Antarctic Circumpolar Current, leading to a relative thermal and biogeographic isolation of the Antarctic fauna. However, the zoogeographical affinities of several taxa from South America and Antarctica have been subject to debate, bringing into question the extent of Antarctic isolation.Herewe present newdata on bryozoan species and their spatial distribution in the Argentine Patagonian (AP) region, as well as an analysis of the bryozoological similarities between deep ranges from Argentina and neighboring regions. A total of 108 species of cheilostome bryozoans (378 samples), belonging to 59 genera was found. Five new genera and 36 new species were found in the AP region, while 71 species were reported for the first time from Argentina. The bathymetric ranges of 94 species (87%) were expanded and a high proportion of the identified species (44.4%) also had an Antarctic distribution. The bryozoological affinities found in the current study between the nearest geographical neighbors are in agreement with the hypothesis of the sequential separation of Gondwana during the Cenozoic. Moreover, a high number of shared species, mainly from the slope, were found in this study between the AP region and Antarctica, thus supporting the idea that the Southern Ocean may have been less isolated over geological time than once thought.Spanish Institute of OceanographyPostprin

Framing the past and future The development and deployment of technological capabilities by the oil majors in the upstream petroleum industry

Available from British Library Document Supply Centre- DSC:DXN056775 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Governance and co-ordination of distributed innovation processes: Patterns of R&D Co-operation in the Upstream Petroleum Industry

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Innovation in 'Low-Tech' Industries

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Exploring the miracle: strategy and management of the knowledge base in the aeronautics industry

We consider here the governance of learning and the diffusion of technological knowledge in the civil aircraft industry. We describe a systemic process by which specialization in knowledge encourages depth whilst breadth is captured through the integration of contributions by the lead manufacturer, which acts as systems integrator. We explore the boundaries of the knowledge bases related to airframe structure and systems and aircraft instrumentation by using patents as tracers, considering the range of scientific and technological disciplines related to the industry as well as the sources of that knowledge. We conclude that knowledge base supporting the aeronautics industry is complex and multidisciplinary, and that firms acting as system integrators have to hold the broadest knowledge bases to co-ordinate design and production. \uc2\ua9 World Scientific Publishing Company